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|Product Name:||Olaparib,Azd 2281||CAS No.:||763113-22-0|
Factory Supply High Purity Olaparib/Azd 2281 CAS 763113-22-0 Inhibitor for Targeted Cancer Therapy
Olaparib/Azd 2281 CAS763113-22-0 Inhibitor for Targeted Cancer Therapy research
Base information of Olaparib/Azd 2281
Product name: Olaparib/Azd 2281
CAS No. 763113-22-0
Soluble in DMSO
Quality: As stated on COA/MS/HPLC reports
Appearance: White Powder
Delivery: Within 3-5days
Shipping: By express TNT/DHL door to door with tracking number provided.
Packaging: 10g/100g/500g/1kg, packaged by Aluminum foil bag.
Quality Reports of Olaparib/Azd 2281
What is Olaparib?
Olaparib is a new type of poly ADP ribose polymerase (PARP) inhibitor, including PARP1, PARP2, and PARP3. PARP mediated a DNA repair mechanism, plays an important role in DNA damage repair and apoptosis, so Ola Pani specific effect on target cell DNA damage repair mechanism, by attacking the carrying BRCA1 and BRCA2 mutation critical vulnerabilities in cancer cells play a role, can be used for breast cancer susceptibility gene (BRCA) mutation and for the maintenance treatment of platinum sensitive recurrent severe ovarian cancer patients.
In ovarian cancer and breast cancer cells, the BRCA mutation is the first hit on cell survival, because it increases the susceptibility to DNA damage. By targeting the PARP controlled backup repair pathway, Olaparib and its similar drugs have achieved a double hit on cell survival. As the two repair signaling pathways were out of balance, the accumulation of DNA damage produced a third hit on the cell.
Remarks: The product is restricted in lab.
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