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|CAS NO.::||130143-01-0||Synonyms::||Cetrorelix Acetate|
|Shelf Life::||2 Years For Cetrorelix Acetate||Certificate:||GMP,ISO|
Chemical Name: Cetrorelix acetate
CAS NO.: 130143-01-0
Synonyms: Cetrorelix acetate
Purity:99% Cetrorelix acetate
Appearance: white powder
Shelf life:2 years for Cetrorelix acetate
Storage:Cetrorelix acetate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Cetrorelix acetate is a synthetic decapeptide with gonadotropinreleasing hormone (GnRH) antagonistic activity. Cetrorelix acetate is an analog of native GnRH with substitutions of amino acids at positions 1, 2, 3, 6, and 10. The molecular formula is C70H92CIN17O14 (Ac-D-Nal1-D-Cpa2-D-Pal3-Ser4-Tyr5- D-Cit6-Leu7-Arg8-Pro9-D -Ala10-NH2), and the molecular weight is 1431 Dalton, calculated as the anhydrous free base.
Cetrorelix acetate is an gonadotropinreleasing hormone (GnRH) antagonist. A synthetic decapeptide, it is used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning).
|Appearance||White powder||White powder|
|Identity by HPLC||The retention is same with the reference substance||Conforms|
|Specific Optical Rotation||-20 to -30°(c=1,50%HAc)||-26.5°|
|Amino Acid Composition||±20% of theoretical||Conforms|
|Purity (by HPLC)||≥98.0%||99.11%|
|Related Substance(By HPLC)||
Largest Single Impurity(%)≤1.0%
|Acetate Content (by HPLC)||≤15.0%||9.7%|
|Water Content (by Karl Fischer)||≤10.0%||2.2%|
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