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135463 81 9 Nootropic Pharmaceutical Raw Materials Coluracetam Mkc -231 / Bci -540

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number 135463 81 9
Minimum Order Quantity 10g
Price negotiable
Packaging Details 10g,50g,1kg bag
Delivery Time 1-3 working days to ship, then about 5-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Payment Method
Supply Ability 1000 kg per month
Product Details
Other Name Mkc -231 / Bci -540 Cas No. 135463 81 9
Appearance White Crystalline Powder Delivery 1-3 Working Days After Payment
Purity 99%min Package Foil Bag,drum
Grade Standard Medical Grade Assay HPLC 99%
High Light

99 Purity Pharmaceutical Raw Materials

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Anastrozole Pharmaceutical Raw Materials

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Product Description

135463 81 9 Nootropic Raw Steroid Powders Coluracetam Mkc -231 / Bci -540

135463 81 9 Nootropic Pharmaceutical Raw Materials Coluracetam Mkc -231 / Bci -540 0

 

Coluracetam Description:
Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease.


Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown


Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.

 

Superlist Name:Coluracetam
Molecular Formula:C19H23N3O3
CAS No.:135463-81-9
Purity:99%
Synonyms:N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Weight:341.40
Appearance:white crystal powder
Boiling Point:634.1°C at 760 mmHg °C
Usage:mainly applied to promote intellectual product. /raw material used in Synthesis/ pharmaceutical raw material

 

Application:
Coluracetam is a nootropic drug of the racetam family. Coluracetam was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.

Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.

 

Benefits of Coluracetam
The first noted benefit of Coluracetam is in ameliorating the effects of glutamate neurotoxicity; cortical cultures were taken from fetal rats that had been treated with a substance that causes glutamate toxicity and these cultures were treated with Coluracetam for 12 to 24 hours. After this exposure period, it was found that Coluracetam ameliorated the effects of the exposure .

 

The second noted benefit of Coluracetam was in reducing the effects of learning deficits in rats, using the Morris Water Maze as a test. Adult rats in the experimental group were treated with a cholinergic neuron-specific neurotoxin and the control group was a population of healthy rats. In the experimental group, Coluracetam greatly reduced the learning deficits associated with the administration of the neurotoxin without causing any expected side effects such as tremor, hypothermia, or salivation. It would appear from this study that Coluracetam had less of an effect on the control group (the healthy rats) than it did on the experimental group .

 

During the Phase 2A trials of Coluracetam by BrainCells Inc, it was noted that 80mg of Coluracetam administered three times per day was somewhat effective in treating Major Depressive Disorder co-morbid with Generalized Anxiety Disorder in those who had no positive effects from at least two other anti-depressants in the past. In the basic group (those administered Coluracetam at 80mg once per day), no significant effects were found compared to placebo; but at 80mg TID, 36% of participants saw a marked improvement in the test used to assess depression .

 

The final noted benefit of Coluracetam is long-term improvements in learning-impaired individuals; rats were given treated with the substance AF64A which is a cholinergic neuron-specific neurotoxin, and then given repeated doses of Coluracetam for 8-days at 3mg/kg/day. The researchers found that even 72 hours after the final administration of Coluracetam, the learning impaired rats still showed improvements in their abilities in the Morris Water Maze. During this experiment, the researchers also tested whether or not Coluracetam was found in the rats system at the time of Water Maze testing; they found that even though the rats were still exhibiting positive effects from the last administration, the concentrations of Coluracetam in their systems were negligible .

 

Coluracetam Dosing
Of the studies cited done on adult rats, the dosing schedule ranged anywhere from 1mg/kg up to 10mg/kg in (per day) . At the high end of that range, the dosing (accounting for Allometric scaling) in an average adult human would be equivalent to 2.9mg/kg; this would work out to 203.5mg/day for someone of an average weight

BrainCells Inc. also recently concluded Phase 2A trials of Coluracetam, under the name BCI-540, where they administered up to 80mg three times per day for Major Depressive Disorder in adult humans (or 1.14mg/kg in an average weight human); 36% of participants showed improvements in their scores on two tests for MDD .

 

135463 81 9 Nootropic Pharmaceutical Raw Materials Coluracetam Mkc -231 / Bci -540 1

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Peptides Specification
MGF 2mg
PEG MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1 10mg
MT-2 10mg
GHRP-2 5mg
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Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
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TB500 2mg
Pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg
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NPP 100mg/ml 150mg/ml
Equipoise 200mg/ml 250mg/ml 300mg/ml
Tren ace 100mg/ml
Tren en 100mg/ml 200mg/ml
Masteron 100mg/ml 150mg/ml
Primobolone 100mg/ml
Supertest 450 450mg/ml
Anomass 400 400mg/ml
Rippex 225 225mg/ml

 

 

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