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96829 58 2 Anti-Obesity Drug Orlistat powder Weight Loss Steroids

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number 96829 58 2
Minimum Order Quantity 100g
Price US $0.75~$1
Packaging Details Aluminum foil bag packing.Or other custom packaging.
Delivery Time 1-3 working days to ship, then about 5-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Payment Method
Supply Ability 100kg per month
Product Details
Name Orlistat Grade Phamaceutical Grade
Function Anti-Obesity Purity 99%min
Cas No. 96829 58 2 MF C29H53NO5
Assay HPLC 99% Color White Powder
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Orlistat Description:
Orlistat is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.

 

Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini.However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.

 

Orlistat Basic information
A new type of lipid - lowering drugs Pharmacological effects Indications Side effects Drug interactions Dosage and Usage Precautions
Product Name:Orlistat
Synonyms:(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER;RO-18-0647;(-)-TETRAHYDROLIPSTATIN;ORLISTAT;N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER;XENICAL;(-)-Tetrahydrolipstatin(EquivalentToOrlistat);Orlipastat
CAS: 96829-58-2
MF: C29H53NO5
MW: 495.73

Product Categories:Pharmaceutical Raw Materials;Miscellaneous Biochemicals;API;Antiobesity Agent;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acids & Derivatives;Heterocycles;ACTOS;Other APIs;Lipid-lowering medicine reducing weight

Orlistat Chemical Properties
Melting point: <50 °C
storage temp.:2-8°C
solubility:DMSO: 19 mg/mL
form: solid
color: white
Purity: 99.0%
Density: 0.976 g/cm3
Appearance: white needle crystal or powde
Quality standard: CP
Appearance: White or kind of white crystalline powder, soluble in water.
Usage: Used for curing obesity. Orlistat is combined with a reduced-calorie diet to promote weight loss. Orlistat also may be used to prevent weight gain after weight has been lost.
Chemical Properties:Off-White Solid

 

.Medical uses
Orlistat is used for the treatment of obesity. The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body fat.After orlistat was stopped, a significant number of subjects regained weight-up to 35% of the weight they had lost.

The incidence of type 2 diabetes in an obese population over four years is decreased with orlistat (6.2%) compared to placebo (9.0%).Long-term use of orlistat also leads to a modest reduction in blood pressure (mean reductions of 2.5 and 1.9 mmHg in systolic and diastolic blood pressure respectively).

 

Applications:
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those not taking the drug over the course of a year. Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.

 

Item Specification Result
Appearance while powder white powder
Identification HPLC retention time Conforms
Melting Point 42 ºC -45°C 42 ºC -45°C
Specific optical rotation -31.0°~-41.0° -36.0°
Purity optical rotation -31.0°~-41.0° -36.0°
Total impurity no more than 2.0% 1.6%
Max Individual impurity no more than 0.5% 0.3%
Water content%(K&F) no more than 0.5% 0.1%
Residual solvents EtOH no more than 0.5% N.D
EtAC no more than 0.5% N.D
n-Heptane no more than 0.5% less than 0.1%
Residue on ignition less than 0.2% 0.10%
Heavy metals no more than 20ppm less than20ppm
Assay (HPLC) no less than 99.0% 99.60%
Conclusion Meets the Requirements

 

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Usage:

 

An antiobesity agent. A pancreatic lipase inhibitor. Antiobesity agent. Antidiabetic;Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor. Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.

 

 

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