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Estrogen Estriol / E3 / Oestriol / 16α - hydroxyestradiol CAS 50-27-1

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number 50-27-1
Minimum Order Quantity 10g
Price negotiable
Packaging Details 10g,50g,1kg bag
Delivery Time 1-3 working days to ship, then about 5-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Payment Method
Supply Ability 1000 kg per month
Product Details
Other Names E3 / Oestriol / 16α - Hydroxyestradiol Cas No. 50-27-1
Appearance White Crystalline Powder Delivery 1-3 Working Days After Payment
Purity 99%min Shelf Life 2 Years
Grade Standard Medical Grade Assay HPLC 99%
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Product Description

Estrogen Estriol / E3 / Oestriol / 16α - hydroxyestradiol CAS 50-27-1

Estrogen Estriol / E3 / Oestriol / 16α - hydroxyestradiol CAS 50-27-1 0

 

Estriol Description:
Estriol (E3), or oestriol, also known as 16α-hydroxyestradiol or as estra-1,3,5(10)-triene-3,16α,17β-triol, is a natural steroidal estrogen and one of the three main estrogens in the human body. Production of estriol by the ovaries is almost undetectable in non-pregnant women.However, during pregnancy, estriol is synthesized in very high amounts by the placenta and is by far the most produced estrogen in the body,although circulating levels are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.

Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy.

 

Estriol Spec.
CAS:50-27-1
Assay:99%
MF: C18H24O3
MW: 288.38
EINECS: 200-022-2
storage temp.: -20°C Freezer
MP: 280-282 °C(lit.)
Appearance: White Crystalline Solid
Usage: A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol.

 

Application:
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.

 

Dosage:
The typical oral dose used in Western Europe is 2 to 5 mg daily, but because much of it is "dumped" by
the liver immediately, this may only ultimately amount to ½ to 1 mg of estriol actually getting into the body.
Many clinicians use an estriol cream that delivers 2 to 5 mg. When made as a cream, the pharmacist
should indicate on the container how much cream it takes to provide the 2 to 5 mg of estriol.
When you deliver estriol to your body via a cream, it is delivered in a much steadier fashion, whereas given orally it is subject to all the variables of how the digestive system and the liver are working from hour to
hour.

An estriol cream that delivers 0.5 mg, used every other day, has been shown to be very effective for treating vaginal atrophy and urinary tract infections. Published studies show that 0.5 mg estriol delivered every other day for 2 weeks, is adequate for most women, and this is how estriol is used by most women in
Europe.

The reason that estriol is used only every other day is because it doesn't clear from the body as fast as the other estrogens and therefore one dose will last for two days. Using it every day can result in excessively high levels. Although estriol does not absorb through the skin as rapidly as estradiol or estrone, studies have shown that topical delivery of estriol is about twenty times more efficient than oral delivery.


Function:
1.Estriol is a Safe and Effective Hormone for Menopausal Women with Hot Flashes and Vaginal Dryness
2.Estriol Protects Against Breast and Uterine Cancers
3.Estriol as a Replacement Estrogen in Breast Cancer Survivors
4.Estriol Prevents Vaginal Atrophy and Urinary Tract Infections
5.Estriol Does Not Cause Blood Clots
6.Estriol Protects the Skin From Aging

 

Estrogen Estriol / E3 / Oestriol / 16α - hydroxyestradiol CAS 50-27-1 1

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Peptides Specification
MGF 2mg
PEG MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1 10mg
MT-2 10mg
GHRP-2 5mg
GHRP-2 10mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
Oxytocin 2mg
TB500 2mg
Pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg
Finished steroid oil Strength
Test prop 100mg/ml
Test e 250mg/ml 300mg/ml
Test cyp 250mg/ml 300mg/ml
Test Suspension 100mg/ml
Sustanon 200mg/ml 250mg/ml 300mg/ml
Deca 200mg/ml 250mg/ml
NPP 100mg/ml 150mg/ml
Equipoise 200mg/ml 250mg/ml 300mg/ml
Tren ace 100mg/ml
Tren en 100mg/ml 200mg/ml
Masteron 100mg/ml 150mg/ml
Primobolone 100mg/ml
Supertest 450 450mg/ml
Anomass 400 400mg/ml
Rippex 225 225mg/ml

 

 

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