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Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number 946870-92-4
Minimum Order Quantity 1 box
Price US $52.5-$285
Packaging Details 0.1mg/1mg per vial 10 vails/box, white box packaging and any method of packing applicable to the product.For safe delivery.
Delivery Time 1-3 working days to ship, about 3-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Reliable Payment Method
Supply Ability 5000 boxes per month
Product Details
Product Name IGF-1 DES Purity 99%min
Grade Standard Medical Grade Cas No. 946870-92-4
Shelf Life 2 Years Assay HPLC 99%
Color White Powder Storage Cold Storage
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HPLC 99 Weight Loss Peptides

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5000iu/ Vial Human Growth Hormone Supplement

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Product Description

Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss

 

Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 0

Synonyms: IGF-1 DES

MW: 7371.4

Appearance: White Powder

Purity: >95%(HPLC)

Source: Chemical Synthesis

 

Sequence:

H-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala-OH

 

Purity: >95%

Bacterial Endotoxins: < 5EU/mg

 

Introduction:

 

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF-1 DES is a truncated form of IGF-1, which mediates many of the growth-promoting effects of growth hormone, with the tri-peptide structure Glycine-Proline-Glutamine cleaved from the N-terminus. It has been isolated from and detected in numerous in vivo sources, including the human brain, bovine colostrum, and porcine uterus. In vitro studies demonstrate that at equal doses DES (1-3) IGF is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action.

 

 

Insulin Like Growth Factor (IGF)-1 (4-70), otherwise known as IGF-1 DES, produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7,372 Da. In vitro studies demonstrate that at equal doses DES (1-3) IGF is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action.

IGF-1 DES is a cleaved form of IGF-1 and contains amino acids 4-70. This structure has allowed the effects of the IGF-1 protein to be amplified in the more stable form of the DES 1,3 molecule peptide protein fragment of Insulin-like growth factor 1. The IGF-1 DES, or insulin-like growth factor DES, comes from the IGF-1 family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone and IGF-1 DES, although shorter, pacts an equal amount of physiological altering protein physical changes. Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' or IGF-1 and more recently through truncation, DES IGF-1.

 

 

The efficacy of insulin-like growth factor I (IGF-I) in enhancing growth in animals with reduced renal mass was investigated in subtotally nephrectomized young male rats. Recombinant human IGF-I was administered by osmotic minipumps for 7 days at two doses, 0.9 and 2.2 mg.kg body wt-1. day-1, and the truncated analogue of IGF-I, des-(1-3)IGF-I, was given at a dose of 0.9 mg.kg body wt-1.day-1. The partial nephrectomy procedure resulted in significantly impaired renal function as evidenced by elevated serum urea and creatinine concentrations, reduced creatinine clearance, and increased average daily urine output. Carcass composition was significantly altered in animals with reduced renal mass; water content increased and fat content decreased, while protein content remained unchanged. Carcass composition was not affected by IGF treatment. Body weight gain, food utilization, and nitrogen balance during the treatment period were significantly increased in rats treated with IGF-I at both the lower and higher doses and in those treated with des-(1-3)IGF-I. The improved nitrogen balance in the des-(1-3)IGF-I group could at least partly be explained by a diminished rate of muscle protein breakdown, as indicated by the reduced urinary excretion rate of 3-methylhistidine. Compensatory hypertrophy of the remnant kidney was significantly increased in the group treated with the high dose of IGF-I. These results suggest that IGF-I may have beneficial effects on somatic growth and nitrogen balance in renal insufficiency, with des-(1--3)IGF-I being particularly effective in reducing the rate of muscle protein breakdown.


 

Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 1

 

 

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Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 2

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Human Growth Hormone Somatropin HGH 191aa Injections Buy Powder 191 aa hgh HGH Growth Hormone 191aa

 

Telegram/Whatsapp/Skype:008613798562250

 

Email:manager@szmallbio.com

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Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 3

Telegram/Whatsapp/Skype:008613798562250

 

Email:manager@szmallbio.com

Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 4Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 5Muscle Building IGF Peptide IGF-1 DES 1mg/vial Growth Hormone For Weight Loss 6

 

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