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Chris karps,SwedenAlways pleasure to work with you Wendy! Good communication, service minded and top notch products .
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99% Pure SARM Steroids AICAR/Acadesine Pharma Grade Powder and Pills for Fat Burning Effective
Place of Origin | China |
---|---|
Brand Name | ML |
Certification | TESTING |
Model Number | Aicar |
Minimum Order Quantity | 10g |
Price | Negotiable |
Packaging Details | Aluminum foil bag packing.Or other custom packaging. |
Delivery Time | 1-3 working days to ship, then about 5-12 working days for delivery |
Payment Terms | , , T/T, Bank transfer and BTC or Another Payment Method |
Supply Ability | 50KG per Month |
Prouduct Names | Acadesine | Purity | 99% |
---|---|---|---|
Specification | 10g/bag,100g/bag,1kg/bag | Grade Standard | Medical Grade |
Cas No. | 2627-69-2 | Shelf Life | 2-3 Years |
Assay | HPLC 99% | Color | White Powder |
High Light | Andarine Pharmaceutical SARM Steroids,AICAR Acadesine Pharma Grade Powder |
99% Pure SARM Steroids AICAR/Acadesine Pharma Grade Powder and Pills for Fat Burning Effective
Quick details:
Product Name |
Aicar |
Aicar Alias |
Acadesine |
Aicar CAS |
2627-69-2 |
Aicar Molecular Formula |
C9H14N4O5 |
Aicar Molecular weight |
258.23 |
Aicar Apperance |
Off-White Powder |
Aicar Assay |
99%min |
Aicar Usage |
Pharmaceutical intermediates. For the treatment of cardiovascular diseases |
AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
AICAR uses metabolic pathways to block certain enzymes, which allows for AMP-activated protein kinase. This can be explained to the layperson like this: once you take a substantial amount of AICAR, it tricks your body at a cellular level in to thinking that exercise has just been performed. Since the body thinks it has just done a considerable amount of exercise, the energy cycle at the cellular level starts converting fuel sources, like fatty acids, to output the energy that was thought to have been spent during exercise. This can have a direct effect on the level of endurance activity and the sustainability of that activity. Insulin sensitivity is also noted to be one action that AICAR produces, as the body will think it just went through a series of exercises. Interestingly, in animal studies with obese mice, AICAR showed all of the peptides benefits for obese diet induced mice, yet the healthy lean mice did not reap any of the benefits of insulin sensitivity or increase in glucose uptake. That being said, the application in bodybuilding does not seem very suitable, as these mechanisms are targeted for the out-of-shape and overweight, so if you are not a top level endurance athlete I just do not see the reason for using AICAR. A much better option would be Cardarine (GW-50156), as this compound is readily activated by exercise, so the need to work out or cardio would be an incentive.
SARMS product list | |||
Product | Cas No | Product | Cas No |
MK-2866 (Ostarine; Enobosarm; GTX-024; S-1) | 1202044-20-9 841205-47-8 | MK-677 (MK-0677; Ibutamoren; Ibutamoren; nutrobal; L 163,191; Ibutamoren mesylate; Crescendo) | 159752-10-0 |
GW501516 (Cardarine) (GSK-516) GW1516 | 317318-70-0 | YK11 (YK-11-OA) | 431579-34-9 |
GW0742 | S4 (Andarine; GTX-007; Acetamidoxolutamide) | 401900-40-1 | |
LGD-4033 (Ligandrol) | 1165910-22-4 | S23 | 1010396-29-8 |
RAD-140 (Testolone) | 118237-47-0 | SR9009 (Stenabolic) | 1379686-30-2 |
SR9011 | 1379686-29-9 | Another products: Peptide,HGH,steroids.... |

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