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Raloxifene Hydrochloride Pharmaceutical Raw Material Raloxifene HCl CAS 82640 04 8

Place of Origin China
Brand Name ML
Certification TESTING
Model Number 82640-04-8
Minimum Order Quantity 10g
Price negotiable
Packaging Details 10g,50g,1kg bag
Delivery Time 1-3 working days to ship, then about 5-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Payment Method
Supply Ability 1000 kg per month
Product Details
Product Name Raloxifene HCL Purity 99% Min
Grade Standard Medical Grade Cas No. 82640-04-8
Shelf Life 2 Years MF C28H28ClNO4S
Assay HPLC 99% Color White To Pale Yellow Powder
Type Auxiliaries And Other Medicinal Chemicals Einecs No. N/M
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Raloxifene Hydrochloride Pharmaceutical Raw Material

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82640 04 8 Pharmaceutical Raw Material

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82640 04 8 Raloxifene HCl Powder

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Product Description

Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

 

 

 

Quick Detail:

 

Raloxifene Hydrochloride
CAS: 82640-04-8
Purity: 99.6%
Molecular formula: C28H28ClNO4S
Molecular Weight: 510.04
Appearance: Light yellow solid
Flash Point: 394.2 °C
Enthalpy of Vaporization: 110.08 kJ/mol
Boiling Point: 728.2 °C at 760 mmHg
Vapour Pressure: 6.46E-22 mmHg at 25 °C
Specification: USP30/BP2005
Payment:T/T, and
Delivery:Within 24hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door)

 

 

 

Abstract

 

Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist (blocking) properties in some tissues while acting as an estrogen receptor agonist (activator) in others.

The main point of variation between these two agents is their tissue selectivity. While raloxifene hydrochloride is a strong anti-estrogen in breast and uterine tissues, it appears to be estrogenic in bone. This allows it to protect bone density, mimicking the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, which is anti-estrogenic in both breast and bone.

In a role that was novel for an anti-estrogen, raloxifene hydrochloride was approved by the FDA for the prevention and treatment of osteoporosis in post-menopausal women. It is also being investigated for several other potential uses, including the treatment and prevention of cardiovascular disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.


Raloxifene Hydrochloride is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women.

It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens. Raloxifene Hydrochloride will not treat hot flashes of menopause and may cause hot flashes to occur. Also, Raloxifene Hydrochloride does not stimulate the breast or uterus as estrogen does.

Raloxifene Hydrochloride lowers the blood concentrations of total and low-density lipoprotein (LDL) cholesterol, the bad cholesterols, but it does not increase concentrations of high-density lipoprotein (HDL) cholesterol, the good cholesterol, in your blood.

Raloxifene Hydrochloride is also used to lower chances of having invasive breast cancer in postmenopausal women with osteoporosis or at high risk of having invasive breast cancer .
This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Raloxifene Hydrochloride is used in certain patients with the following medical conditions:

Breast cancer prevention in high-risk women who have already gone through menopause.


Application


May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents or in whom such therapies are contraindicated.


Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).


Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established. Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.

 

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1. Quality : we deal with steroid relevant products over 10 years, and have many stable customers from all over the world. All of them witness our products' quality.
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Application:

Raloxifene is indicated for the treatment and prevention of osteoporosis in postmenopausal women. It is also used for reduction of risk and treatment of invasive breast cancer, and it also reduces breast density.For either osteoporosis treatment or prevention, supplemental calcium and/or vitamin D should be added to the diet if daily intake is inadequate.

Raloxifene is used to prevent and treat bone loss (osteoporosis) in women after menopause. Maintaining strong bones by slowing bone loss helps to reduce the risk of fractures.

Raloxifene may also lower the chance of getting a certain type of breast cancer (invasive) in women after menopause.

May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents or in whom such therapies are contraindicated.

Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).

Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established. Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.

 

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Raloxifene Hydrochloride Pharmaceutical Raw Material Raloxifene HCl CAS 82640 04 8 0
 
 
 

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