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99% Purity SARMs Raw Powder Myostatin Inhibitor AICAR 2627-69-2 for Bodybuilding

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number Aicar
Minimum Order Quantity 10g
Price Negotiable
Packaging Details Aluminum foil bag packing.Or other custom packaging.
Delivery Time 1-3 working days to ship, then about 5-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Payment Method
Supply Ability 50KG per Month
Product Details
Other Name Acadesine Purity 99%min
MOQ 10g Grade Standard Medical Grade
Cas No. 2627-69-2 Shelf Life 2-3 Years
Assay HPLC 99% Color White Powder
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Product Description

99% Purity Aicar CAS 2627-69-2 Sarm Raw Powder For Bodybuilding

99% Purity SARMs Raw Powder Myostatin Inhibitor AICAR 2627-69-2 for Bodybuilding 0

Quick Details:

Alias AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS 2627-69-2
EINECS 220-097-5
Assay 99%
Properties White or off-white powder.
Molecular Formula: C9H14N4O5
Molecular Weight 258.23
Melting Point: 214-215 °C
Storage Instructions Store at -20°C (desiccating conditions).
Solubility Overview Soluble in water to 50 mm and in DMSO to 100 mm (with heating)
Usage Pharmaceutical intermediates. For the treatment of cardiovascular diseases.

 

 

2. History:

AICAR has been used medically to help with restriction of blood supply to tissues, called ischemia. Interestingly, in the 1980’s it was sometimes used during surgery to help preserve blood flow to the heart. These days, AICAR shows to be promising in diabetes treatment because of its ability to increase metabolic activity of tissues by changing the composition of muscles in the body.

 

 

3. Description:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.

 

 

4. Function:

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

 

5. Usage:

In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducingor any other unwanted Hormone effect. Recent research has shown AOD9604 to be an extremely potent and effective fat burner. Metabolic is developing AOD-9604 for the potential treatment of obesity. Research studies have shown that AOD9604 actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.

 

These segments of the synthetic peptide AOD9604 have been researched for their in vivo effects in laboratory mice musculus. Results have shown that AOD9604 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, AOD9604, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).

 

Glucose uptake stimulant; AMPK activator; Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

 

99% Purity SARMs Raw Powder Myostatin Inhibitor AICAR 2627-69-2 for Bodybuilding 1
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Email:manager@szmallbio.com

 

SARMS product list
Product Cas No Product Cas No
MK-2866 (Ostarine; Enobosarm; GTX-024; S-1) 1202044-20-9 841205-47-8 MK-677 (MK-0677; Ibutamoren; Ibutamoren; nutrobal; L 163,191; Ibutamoren mesylate; Crescendo) 159752-10-0
GW501516 (Cardarine) (GSK-516) GW1516 317318-70-0 YK11 (YK-11-OA) 431579-34-9
GW0742   S4 (Andarine; GTX-007; Acetamidoxolutamide) 401900-40-1
LGD-4033 (Ligandrol) 1165910-22-4 S23 1010396-29-8
RAD-140 (Testolone) 118237-47-0 SR9009 (Stenabolic) 1379686-30-2
SR9011 1379686-29-9 Another products: Peptide,HGH,steroids....
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