CAS 2627-69-2 AICAR 99% White SARMS Powder Activated Protein Kinase (AMPK)

Basic Info.

Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Melting point 214-215 °C
solubility H2O: >10 mg/mL
Appearance: White powder
Water Solubility Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

HOW IT WORKS

AICAR will trigger AMP activated protein kinase (AMPK), leading to glucose uptake by cells of skeletal muscle. In fact, The Howard Hughes Medical Center and Salk Institute ran a series of experiments with AICAR in the 2000’s. In these studies they found out that mice that were given AICAR could run 44% further, even without training for it. Consequently, once endurance athletes got word of this amazing compound, AICAR was being used without any regulation or fear of testing until 2011.

STACKING WITH GW-501516

Both AICAR and GW (cardarine) are on WADA’s banned substances list, and if used together they make a potent endurance stack. One of the differences between the two is that GW is a PPAR-delta agonist, while AICAR is a PPAR-delta AMPK axis agonist.

In terms of doping, GW is easily detectable for up to 40 days in urine tests, as it is not a naturally occuring substance in the body. Meanwhile, AICAR is a naturally occuring substance in the body, so this makes it more difficult to test for. To combat this, a baseline value was established, which determines if someone is using AICAR to dope with. Nevertheless, it has still been proven to be harder to catch cheaters using AICAR than GW. For instance, a Spanish team cycling doctor was caught with AICAR in his luggage, so we know cyclists are using it - they just aren’t getting caught.

DOSAGE

Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition.

CONCLUSION

AICAR seems to have run its course in the PED world, especially with the competition represented by GW. Cardarine is much safer to use and is way easier on the wallet.

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