DSIP 2mg Delta Sleep-inducing steroid Raw Peptide 62568-57-4 for bodybuilding

Dsip Peptides Steroids DSIP Delta Sleeping Inducing Peptide DSIP 5Mg/vial For Sleep - aid

Quick Detail:

Unit Size :2 mg/vial
Unit Quantity :1 Vial

Delta sleep-inducing peptide(DSIP)

Sequence:Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification: 2mg/vial;
CAS#: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Purity: 99.0%min

2. Description:

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP),adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells

and in the pancreas where it co-localises with glucagon. In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats.It is unknown where DSIP

is synthesized.

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP),adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells

and in the pancreas where it co-localises with glucagon.

In the brain its action may be mediated by NMDA receptors.In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids

 Applications:

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like

immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.

Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release
Stimulates release of luteinizing hormone (LH)
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
Roles in physiological processes
Can act as a stress limiting factor.
May have a direct or indirect effect on body temperature and alleviating hypothermia.
Can normalize blood pressure and myocardial contraction.
It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.
There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep, (PS)while some studies show no correlation.Stronger effects on sleep have been noted for the synthesized analogues of DSIP.

It may have an impact on human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.

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