Peptide Steroid Hormones Melanotan-I / MT-1 for medical usage

99% High Purity Melanotan 1 / MT I for Skin Care and Weight Loss

Quick Detail:

MT 1 Model No.: Melanotan I 10mg/vial, 100vial/kit
Melanotan Export Markets: Global
Melanotan I Product Description
Melanotan I
CAS: 75921-69-6
Formula: C78H111N21O19
Chain: AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-PRO-Val-NH2
Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Purity(by HPLC): >99.00%~99.90%
Total Impurities(by HPLC): 1.00%~0.05%
Single Impurity(by HPLC): <0.50%~0.08%
Origin: China (Mainland)
Storage conditions: Aviod shunshine and keeping stoppered

Description:

MT-1 (or Melanotan I, or Afamelanotide, or CUV-1647)is a synthetic analog of peptides nature of endogenous melanocortine peptide alpha-melanocyte stimulating hormone. It has hormones nature as well as common proteins features, its molecular

weight/mass is 1646.88 and its molecular formula is C78H111N21O19.

Melanotan-1 Mechanism of Action - How it Works!
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

 Applications:

Start with a dose of 1mg daily for the first two or three days and, if level of side effects permit, look to increase dosage by 0.25mg every day over the next several days until you reach a daily dosage of 2-3mg. This level should be adequate for most users, though some may wish to increase yet further,perhaps as high as 5mg daily in order to achieve a very deep tan. A maintenance phase as describedabove is then used.

Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction,Melanotan-has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.

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