Hexarelin Acetate HEX Hexarelin 2mg steroid peptide for treatment 140703-51-1

Hexarelin Acetate 10mg / Vial Peptides Bodybuilding Supplements 140703-51-1

Quick Detail:
Hexarelin
Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular formula: C47H58N12O6
MW : 887.04022
CAS number: 140703-51-1
MS:
PubChem: CID 5464109
Synonyms: Hexarelin Acetate, HEX, Examorelin
HS Code : 2937190090
Appearance : White Powder
Purity : 98%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation
Usage : A synthetic can promote GH release six peptide, clinically used in the treatment of growth
hormone secretion deficiency.

Description:

Hexarelin Indications: Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to
GHRP-6, in the grow factor family which stimulates the release of grow hormone (GH). It can be
used medically to treat GH deficiency. Hexarelin is a good all purpose anabolic. Also, since we
know thatIGF and GH use produces a shutdown of your endogenous levels of those hormones,
Hexarelin also seems very useful for "GH-PCT" or "IGF-PCT", as it can help restore your natural
levels of those hormones after a cycle of them.

Examorelin (INN) (developmental code names EP-23905, MF-6003), also known as hexarelin, is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue which
was developed by Mediolanum Farmaceutici.It is a hexapeptide with the amino acid sequence His-D-
2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 which was derived from GHRP-6 (which, in turn, is an analogue
of ghrelin).
Examorelin substantially and dose-dependently increases plasma levels of growth hormone (GH) in animals and humans. In addition, similarly to pralmorelin (GHRP-2) and GHRP-6, it slightly and dose-dependently stimulates the release of prolactin, adrenocorticotropic hormone (ACTH), and cortisol in humans.There are conflicting reports on the ability of examorelin to elevate insulin-like growth factor
1 (IGF-1) and insulin-like growth factor-binding protein 1 (IGFBP-1) levels in humans, with some
studies finding no increase and others finding a slight yet statistically significant increase.Examorelin
does not affect plasma levels of glucose, luteinizing hormone (LH), follicle-stimulating hormone (FSH),
or thyroid-stimulating hormone (TSH) in humans.
Examorelin releases more GH than does growth hormone-releasing hormone (GHRH) in humans,and produces synergistic effects on GH release in combination with GHRH, resulting in "massive" increases
in plasma GH levels even with only low doses of examorelin.Pre-administration of GH blunts the
GH-releasing effect of examorelin, while, in contrast, fully abolishing the effect of GHRH. Pre-treatment with IGF-1 also blunts the GH-elevating effect of examorelin. Testosterone, testosterone enanthate,
and ethinyl estradiol, though not oxandrolone, have been found to significantly potentiate the GH-releasing effects of examorelin in humans.[18][19] In accordance, likely due to increases in sex steroid levels, puberty has also been found to significantly augment the GH-elevating actions of examorelin
in humans.

Applications:
Ghrelin is an appetite-regulating factor secreted from peripheral organs that is involved in regulation
of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by
the pituitary gland. The pathway activated by binding of ghrelin to the growth hormone secretagogue
receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase,
Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. One of the important
features of GHSR1a displays constitutive activity possessing basal activity in the absence of an
agonist, resulting in a high degree of receptor internalization as well as of signaling activity.Inverse
agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity.This
activity seems to provide a tonic signal required for the development of normal height, probably
through an effect on the GH axis.

Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors
separate from the GH releasing properties. The peptide can directly aid in cardio protective left ventricular pressure issues, as well as, help healing scar tissue on the heart. Studies on lean and
obese lab rats concluded that while lean rats were able to take advantage of the GH plasma increase better than the obese rats (the healthier the rat the more hexarelin effectively produced and utilized
GH), obese rats did not see the same advantage. Separate from the studies that monitored GH, both lean and obese rats both received all of the cardio protective properties of hexarelin.

Contact US