Peptide Steroid Hormones PT141 / Bremelanotide CAS 189691-06-3 for Sexual Treat

Natural Medical Peptides PT141 Supplements Bremelanotide / PT-141 5mg/vial for Female Sex Enhancement

Molecular Formula: C50H68N14O10
Molecular Weight: 1025.16
CAS NO:189691-06-3
Sequence:H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
1.Appearance White powder White powder
2 Solubility Soluble in water and 1% acetic acid Conforms
3 Specifical Optical Rotation -50°~-60°(c=1,1%HAc) -55.65°
4 Peptide Purity (By HPLC) ≥ 98.0% by area integration 99.67%

PT141 Information:

Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors.

According to Palatin Technologies' original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than melanotan II. However, in human clinical trials, bremelanotide has, similarly to melanotan II, been found to produce nausea and vomiting (though yawning, stretching, and loss of appetite do not seem to have been reported). Other side effects reported for bremelanotide in human clinical trials include transient facial flushing, sweating, somnolence, headache, dizziness, dysgeusia (altered sense of taste), hypertension, and skin hyperpigmentation.

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