White Powder Polypeptide Hormones PEG-MGF PEGylated Mechano Growth Factor for Bodybuilding

Polypeptide Hormones PEG-MGF PEGylated Mechano Growth Factor for Bodybuilding

1. Quick Detail:

Unit Size :2 mg/vial
Unit Quantity 1 Vial
Synonyms :peg MGF,Mechano growth factor,IGF-1 EC
Molecular :Formula C121H200N42O39
Molecular Weight :2948.15+(1800-2000)
Sequence :PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-D-Arg-D-Arg-Lys-Gly-

Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Appearance :White Powder
Identity (ESI-MS) :2948.15±3.0(MGF)
Source :Chemical Synthesis
Storage :Lyophilized Peg MGF is stable at room temperature for 90 days,however it should be stored

in a freezer below -8C for any extended period of time. After reconstituting Peg MGF should be

refrigerated at temperatures not to exceed 36 F.

2. Description:

PEG-MGF, or PEGylated Mechano Growth Factor is a new and innovative form of MGF that

outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases

stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process

required for growth of adult muscle. Natural MGF is made locally and does not travel into the

bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into

the bloodstream. MGF is only stable in the blood stream for only a few minutes.

PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule

(in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow

the MGF to be carried through the blood stream without being broken down.

MGF exhibits local effects in skeletal muscle and without cannot travel through the body without

modification. The problem with synthetic MGF is that it is introduced intramuscularly and is water

based so it goes into the blood stream. When used this way, MGF only remains stable in the blood

stream for a few minutes. Biologically produced MGF is made locally and does not enter the

bloodstream. It is also short acting so stability is not an issue. By PEGylating the MGF it is almost as

efficient as local produced MGF when used intramuscularly. This is accomplished by surrounding part

of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule.

The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites

of the peptide are still free to do their biological function. In this case the shell is a negative charged

shield against positively charged compounds that would affect the protein. TNeurological research has

shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide

in serum/blood.

Why Mechano Growth Factor? Resistance training or more specifically, a training that causes our

muscles to work beyond their usual power leads to that familiar ‘burning’ sensation we all have had a

chance to experience during an exercise. What happens to our muscles at that point is the following:

Every muscle is a cluster of muscle fibers (muscle cells), which at the point of extreme efforts tend to

tear. The tearing of the muscle fibers is what causes the burning sensation. The torn parts form

certain ‘cavities’ in the muscle tissue and those cavities represent a chance for a muscle to grow. After

those ‘cavities’ are filled up with the muscle ‘matter’, we are left with a muscle of an increased mass.

Why ‘Mechano’? Because tearing of the muscle fibers is an actual mechanical damage, and the only

way to achieve that kind of damage is through mechanical stimulation of the muscle tissue. Why ‘

Growth Factor’? Because Mechano Growth Factor is responsible for accelerated muscle

build-up processes. Besides accelerating muscle build-up processes Mechano Growth Factor

also helps create new muscle cells. That’s a simplified way of looking at the whole process.

We will explain a few more details behind the workings of the Mechano Growth Factor and

PEG-MGF shortly.

Mechano Growth Factor is a peptide hormone, a natural physiological byproduct created in a human

body as a result of an exercise. Mechano Growth Factor (MGF) and IGF-1 (Insulin-like Growth Factor)

are isoforms. Isoform is a protein with a slightly different form but usually a similarfunction as its

‘fellow’ isoform protein. Both, MGF (which is a liver derived hormone) and IGF-1 (which is produced

in the muscles) have anabolic effects, but the anabolic powers of the MGF are greater than those of

IGF-1. Anabolic quality of a substance is such that increases the levels of synthesis, either at a

molecular or a cellular level, meaning the Mechano Growth Factor has a greater sensitivity to damages

caused to muscles by exercise and induces the synthesis of a greater amount of proteins in skeletal

muscles.

Another favorable effect of the Mechano Growth Factor is its ability to activate the satellite cells of

muscles (myosatellite cells). Myosatellite cells behave as stem cells. Once they are activated they fuse,

form myoblastst, proceed to differentiate and form entirely new muscle cells. Again, the result is muscle

growth.

But what about PEG-MGF? Why do we at BeFit4Free produce the PEGylated version of the Mechano

Growth Factor if the MGF on its own has so much potential anyway?

PEGylated protein (PEG-MGF) is the one that has Polyethylene Glycol added to it. The role of the

Polyethylene Glycol molecule is to preserve the integrity of the Mechano Growth Factor. Unlike the

naturally produced Mechano Growth Factor, the injected MGF needs to enter the circulatory system.

That is where the problem for the MGF arises. MGF is not stable in such environment and in order

to be able to reach its final destination and fulfill its role it needs to be PEGylated (and turned into

PEG-MGF). Polyethylene Glycol serves as a kind of a shell protecting the MGF from reacting

to its surroundings before it reaches its final destination. It makes the PEG-MGF much more

stable and long-lasting than Machano Growth Factor could be on its own.

3. Applications:

Typical dosage of PEG-MGF is between 200mcg. – 400mcg. per week but many bodybuilders have

said to “research” this peptide at dosages exceeding 1,500 mcg weekly with no adverse effects.

Because PEG MGF can cause site specific muscle growth, it is recommended to inject PEG MGF

bi-laterally to ensure symmetrical gains. The most effective test results were experienced in users

injecting the PEG MGF post exercise.

Mechano Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, Mechano Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF

is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue.

By PEGylating the Mechano Factor (MGF) it is almost as efficient as local produced Mechano Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene

glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are

still free to do their biological function. In this case the shell is a negative charged shield agains

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