Pentadecapeptide BPC 157 Polypeptide Hormones CAS 137525-51-0 for Muscle Growth

1. Quick Detail:
Unit Size :2 mg/vial
Unit Quantity :1 Vial
CAS NO. :137525-51-0
Synonyms :Bpc 15, Bpc-157, Booly protection compound 15
Molecular Formula :C62H98N16O22
Molecular Weight :1419.53552
Sequence :Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Appearance :White Powder
Purity :98.06%
Source Chemical :Synthesis
Storage :Lyophilized BPC 157 is stable at room temperature for 90 days,however it should be stored

in a freezer below -8C for any extended period of time. After reconstituting BPC 157 should be

refrigerated at temperatures not to exceed 36 F.

2. Description:

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection

compound (BPC) Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence

of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth,

cell survival, and cell migration

Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.

BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD)

(PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular

wound healing effect. It also has shown to interact with the NO-saystem, providing endothelium

protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression

of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome

and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may

counteract the problems commonly exercised in the use of peptidergic agents, particularly those used

on a long-term basis

3. Applications:

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection

compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been

demonstrated to accelerate the healing of many different wounds, including transected rat Achilles

tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance

healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or

without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth

of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon

was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H2O2 stress. BPC 157 markedly increased the in

vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter

migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on

culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC

157treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by

Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently

increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157

promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress,

and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the

FAK-paxillin pathway.

nbsp;was responsible for pituitary stimulation. In 1999 researchers Goa and Prakash checked

sermorelin GH as provocative tasting method for deficiency of endogenous G-hormone.

The most known features of this research compound are increasing lean muscular tissue mass,

reducing fat, increasing bone tissue density and even enhancing functioning of immune system. It

complies with certain amino-segment of natural long-chained GHrh. Sermorelin helps to convert

exceeded volume of GH by liver into IGF-1.