Legal Follistatin 344 Pharmaceutical Raw Material Bodybuilding Supplement

Legal Follistatin 344 Pharmaceutical Raw Material Bodybuilding Supplement

1. Follistatin 344 quick detail:

follistatin 344, Peptide Follistatin 344

Specification:(1mg/vial,10vial/box)
Standard: USP Grade, GMP
Function:Bodybuilding
Grade Standard:Medicine Grade
Appearance:Sterile Filtered White Lyophilized (Freeze-Dried)
Purity(by HPLC):>99.00%~99.90%
Total Impurities(by HPLC):1.00%~0.05%
Single Impurity(by HPLC):<0.50%~0.08%
Storage Conditions:Aviod Shunshine and Keeping Stoppered
Export Markets:Global
Trademark:CBT
Packing:as Your Requirement
Standard:USP

2. Follistatin 344 Description:

Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone

inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid

(aa) protein with a 29 aa signal sequence, an N terminal atypical TGF binding domain, three Follistatin

domains that contain EGF like and kazal like motifs, and a highly acidic C terminal tail. Follistatin is a

secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally

discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary

hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can

inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some

other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids.

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344

containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor

mRNA. There is evidence linking polycystic ovary syndrome and follistatin. Follistatin binds directly to

activin and functions as an activin antagonist. It specific inhibitor of the biosynthesis and secretion of

pituitary follicle stimulating hormone. Subunit : Monomer (Potential).Subcellular Location : Secreted.

Tissue Specificity : Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

Similarity : Contains 3 follistatin-like domains. Contains 3 Kazal-like domains. Contains 1 TB (TGF-beta binding) domain.

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