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White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial

Place of Origin China
Brand Name MALL
Certification TESTING
Model Number Gdf-8
Minimum Order Quantity 1 box
Price US $288-$315
Packaging Details 1mg per vial 10 vails/box, white box packaging and any method of packing applicable to the product.For safe delivery.
Delivery Time 1-3 working days to ship, about 3-12 working days for delivery
Payment Terms , , T/T, Bank transfer and BTC or Another Reliable Payment Method
Supply Ability 5000 boxes per month
Product Details
Purity 99% Min Grade Standard Medicine Grade
Product Name Gdf-8 Shelf Life 2 Years
Type Auxiliaries And Other Medicinal Chemicals Assay HPLC 99%
Color White Powder Storage Cold Storage
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Product Description

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 0

Myostatin/ GDF-8 Description:

 

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a protein that in humans is encoded by the MSTN gene. It isproduced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide acting as a negative regulator of myostatin. Recombinant human Myostatin Propeptide is a non-glycosylated protein, containing 244 amino acids, with a molecular weight of 27.8 kDa. Our Myostatin 1mg is Tagged. The tags are chains/pile of amino acids/proteins, it is foreign protein that will cause immunization reaction in most cases.

 

 

 Biochemistry

 

Myostatin is a member of the TGF beta superfamily of proteins.

Human myostatin consists of two identical subunits, each consisting of 109 amino acid residues. Its total molecular weight is 25.0 kDa. The protein is made in an inactive form. For it to be activated, a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the now-active COOH-terminal dimer.

Myostatin binds to the activin type II receptor, resulting in a recruitment of a coreceptor called Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Recently, myostatin has also been shown to inhibit Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis.

Therefore, myostatin acts in two ways, by inhibiting muscle differentiation and by inhibiting Akt-induced protein synthesis.

 

 Discovery and sequencing

 

The gene encoding myostatin was discovered in 1997 by geneticists Alexandra McPherron and Se-Jin Lee who also produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring myostatin "nulls" have been identified in cattle, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.


 

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 1

 

 

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1. We offer RESHIP service with free cost if goods were catched by custom.

 

2. Free Sample for you, Just pay shipping cost.

 

3.Full experience of large numbers containers loading in Chinese sea port.


4. We provide more customized services:Products, Labels, Boxes.....


5. payment term:,, Bank Transfer and BTC or Another Payment Method.

Human Growth Hormone Somatropin HGH 191aa Injections Buy Powder 191 aa hgh HGH Growth Hormone 191aa

 

Telegram/Whatsapp/Skype:008613798562250

 

Email:manager@szmallbio.com

Human Growth Hormone Somatropin HGH 191aa Injections Buy Powder 191 aa hgh HGH Growth Hormone 191aa

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 3

Telegram/Whatsapp/Skype:008613798562250

 

Email:manager@szmallbio.com

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 4White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 5

 

White Powder Research Peptide Human Myostatin Propeptide Gdf-8 1mg/Vial 6

Contact US

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Email:manager@szmallbio.com
 
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