Human Growth Hormone Polypeptide Freeze Drying Lyophilization Triptorelin Acetate 57773-63-4

CAS 57773-63-4 Peptide Steroid Hormones Triptorelin 2mg Muscle building

Triptorelin Acetate Specifications:

Triptorelin Acetate Description:

1. Product Name: Triptorelin Acetate
2. Sequence: GLP-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-Gly-NH2
3. CAS No. 57773-63-4
4. Molecular Formula: C64H82N18O13
5. Molecular Weight: 1311.46
6. Purity (HPLC)98.0% min.
7. Appearance: White powder
8. Single Impurity (HPLC) 1.0%max
9. Amino Acid Composition ± 10% of theoretical
10. Peptide Content (N%) ≥ 80.0%
11. Water Content(Karl Fischer) ≤ 6.0%
12. Acetate Content (HPIC)≤ 15.0%
13. MS(ESI)Consistent
14. Mass Balance 95.0~105.0%
15. Specific Rotation (20/D) -65.0~-75.0° (c=0.5 1%HAc)

Triptorelin (GnRH)

Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh). In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range norMLy seen after surgical castration occurs approximately two to four weeks after initiation of therapy. Systematic IUPAC Name: [d-Trp6]GnRH [edit]References Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab 13 Suppl 1: 723â€"37. PMID 10969915. Padula AM (August 2005). "GnRH analoguesâ€"agonists and antagonists". Anim Reprod Sci 88 (1â€"2): 115â€"26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640.

Application:

Triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions, and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.
In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl.In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone, known as a flare effect. In men a reduction of serum testosterone levels into the range norMLy seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

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