IGF1 - LR3 Muscle Building Peptides Polypeptide Lyophilized Powder CAS 946870-92-4

What is IGF-1 Lr3?

IGF-1 Lr3 (Insulin-like Growth Factor-I Long R3) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), as well as a 13 amino acid extension peptide at the N-terminus. IGF-I Lr3 is significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins.

How does IGF 1 LR3 works?

IGF 1 LR3 is able to exert its beneficial effects such as increased muscle mass through inducing muscle hyperplasia. Hyperplasia is a state wherein there is an increase in the number of new muscle cells. It also has the ability to improve supplement uptake you are currently using. In addition to this, it is able to decrease binding of IGF 1 on binding proteins. These binding proteins actually prevents the biological activities of IGF hence, inhibiting its function through the use of Long R3 IGF-1 could greatly benefit users in developing improved muscle physique.

IGF-1 Lr3 Benefits:

● Enlarged amino acid transporting cells

● Increased protein production

● Decreases LDL Cholesterol

● Amplified glucose transporting

● Augmented RNA combination

● Stimulates muscle growth

● Regenerates nerve tissue

● Improves the production of white blood cells

Recommended Dosing:

Usual dosages ofIGF-1 LR3 are 20mcg to around 60mcg per day. IGF is usually available by the milligram (1000mcg), which is equivalent to using 20mcg a day for 50 days.

Half Life: About 20-30 hours

How to Take:

IGF-1 LR3 (IGF-1 LONG R3) is taken by Injecting intramuscularly i.e. injecting 20mcg into one bicep and 20mcg into the other.

Description:

IGF-1 LR3, also known as Long-Arginine-3-IGF-1, is an analogue of human IGF-1 that has been modified to include a 13 amino acid N-terminus extension and the substitution of Arginine for Glutamic Acid at position 3. As a result of these modifications, IGF-1 LR3 is approximately three times more potent than IGF-1 and possesses an increased half-life due to lowered affinity for binding to the Insulin-Like Growth Factor-Binding Proteins (IGFBPs). IGF-1 LR3 retains the ability to bind agonistically to the IGF-1 receptor with improved metabolic stability, relative to IGF-1. The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.

Igf1LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the MUSCLE WHERE ITS INJECTED! So think of it as muscle cell proliferation, or even the splitting of the cell so 1 becomes 2... That's why its perfect on cycle when you get increased muscle cell growth too. But why is IGF better than HGH? The reason being is HGH causes IGF levels to rise in the liver first, then then the muscle, Whereas IGF-LR3 causes localized IGF levels to rocket. Igf1lr3 As you all know is the long acting version of Igf1, Taking its active potential up towards 20 hours, But along with its ability to stimulate the growth of satellite muscle cells and helping them to mature into new muscle fibers it holds the ability to increase the uptake of many supplements we currently use, And it can cause the enhanced recovery of testicle size, and prevent muscle loss even in PCT. Plus another reason its so potent is because of the decreased binding of Long R3 Igf1 to all known IGF binding proteins. These binding proteins norMLy inhibit the biological actions of IGF.. not so with this long acting version.

IGF-1 LR3 is a version of IGF-1 which is made not to react with IGFBG, therfore, it has increased activity, stability in comparison to the endogenous IGF-1. IGF-1 is released in the liver and binds to the IGF receptors within the cells, which ultimately causes a stimulation of cell growth (both causing new tissue formation and existing tissue growth) and an inhibition of cell death. IGF1 LR3 allows for many of the growth-promoting effects of growth hormone insulin-like growth factors also know as IGF's. IGF-1 LR3 comprises a family of peptides (protiens) that play important roles in mammalian growth and development. IGF1 LR3 is also known as Long R3 IGF-1 or Insulin-Like Growth Factor-I Long Arg3. The Long R3 IGF-1 version is significantly more potent than regular IGF-1. The enhanced potency is due to the decreased binding of IGF1 LR3 to all known IGF binding proteins. These binding proteins norMLy inhibit the biological actions of IGF's therefore IG-1 LR3 has been shown to have increased efficacy and function. This IGF-1 LR3 analog of IGF-1 has been created with the purpose of increasing the biological activity of the IGF peptide. IGF1 LR3 is also known as Long R3 IGF-1 or Insulin-Like Growth Factor-I Long Arg3. This is a human recombinant, single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9200 Daltons. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). The LR3 is a long-term analog of human IGF-1, specifically designed and manufactured for mammalian cell culture to support large-scale manufacturing of recombinant biopharmaceuticals. Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin'. IGF-1 LR3 is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-I is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperplasia. This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. The most effective form of IGF-1 is considered to be IGF-1 LR3. This formula has been chemically altered to avoid binding to proteins in the human body, and to increase the half life, approximately 20-30 hours.

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